The forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesis
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چکیده
منابع مشابه
Forkhead transcription factors: key players in development and metabolism.
Transcription factors are modular proteins where distinct functions, such as DNA binding, trans-activation or transrepression, are often contained within separable domains. DNA-binding domains tend to be particularly well conserved and can be used as the basis for a classification that reflects phylogenetic relationships. Transcription factors with the same basic design in their interaction wit...
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Colorectal cancer (CRC) is amongst the most widespread cancers and is a most common cause of cancer associated mortality universally. Since previous decades, it has been cleared that CRC develops owing to the buildup of a series of genetic and epigenetic changes in the normal colonic epithelium. Regardless of the current development in surgery and therapies, overall survival of end stage CRC pa...
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Diabetic cardiomyopathy (DCM) is a disorder of the heart muscle in people with diabetes that can occur independent of hypertension or vascular disease. The underlying mechanism of DCM is incompletely understood. Some transcription factors have been suggested to regulate the gene program intricate in the pathogenesis of diabetes prompted cardiac injury. Forkhead box transcription factor 1 is a p...
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Forkhead box (Fox) proteins are an extensive family of transcription factors, which play a key role in the regulation of crucial biological processes, including cell proliferation, differentiation, metabolism, tissue homeostasis, senescence, survival, apoptosis, and DNA damage repair (1). The unifying feature of Fox proteins is the “forkhead” box, a sequence of about 100 amino acids that enable...
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Forkhead box O (FoxO) transcription factors play important roles in cellular physiology and biology. Recent findings indicate that FoxOs are also involved in the development of major depressive disorder. Alterations in the upstream molecules of FoxOs, such as brain derived neurotrophic factor or protein kinase B, have been linked to depression. Antidepressants, such as imipramine and venlafaxin...
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ژورنال
عنوان ژورنال: Molecular Cancer
سال: 2019
ISSN: 1476-4598
DOI: 10.1186/s12943-019-0938-x